Table 1.
A list of compounds in the published literature known to inhibit PRRSV replication and IC50 values for those estimated. NP – not published.
| Compound | IC50 | Reference |
|---|---|---|
| Macrolide antibiotic | ||
| Bafilomycin | ∼0.2 μM | Kreutz and Ackermann (1996) |
| Cellular ion transport targeting agents | ||
| Verapamil | NP | Kreutz and Ackermann (1996) |
| Amantadine | <0.2 μM | |
| Pyrithione | NP | te Velthuis et al. (2010) |
| Endosomal acidification blockers | ||
| Ammonium chloride | <0.5 mM | |
| Chloroquinone | >6 μM | |
| Monensin | NP | |
| Plant derived lectins | ||
| Indigowoad root polysaccharide | NP | van der Meer et al. (2007) |
| Hippeastrum hybrid agglutinin | >2 μM | |
| Galanthus nivalis agglutinin | >2 μM | |
| Cymbidium sp. agglutinin | NP | |
| Urtica dioica agglutinin | 4.8 ± 3.2 μM | |
| Non-plant derived lectins | ||
| Pradimicin-A | >120 μM | van der Meer et al. (2007) |
| Cyanovirin-N | NP | |
| Chelator | ||
| N-acetylpenicillamine | NP | Jiang et al. (2010) |