Fig. 5.

Enhanced survival rate after FMDV challenge by single or combination with Ad-porcine IFN-α, Ad-siRNA, and ribavirin in suckling mice Suckling mice received intraperitoneal injections of 2 × 10⁷ TCID₅₀ Ad-porcine IFN-α and Ad-siRNA, and 0.01 mg ribavirin at 24 h or 6 h before FMDV infection. Ad-porcine IFN-α was administered 24 h before FMDV infection and ribavirin was administered 6 h before FMDV infection except for combination group 2 (A and C). Combination group 2 received a mixture of Ad-porcine IFN-α and ribavirin 24 h before FMDV infection. Combination group 1 received 1 × 10⁷ TCID₅₀ each of Ad-porcine IFN-α and Ad-siRNA (B and D). Combination group 2 received 2 × 10⁷ TCID₅₀ each of Ad-porcine IFN-α and Ad-siRNA. Suckling mice were challenged with 125 LD₅₀ (A and B) or 250 LD₅₀ (C and D) FMDV (O/SKR/2002). Animals were monitored for 7 days.