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Inhibition of HCoV-NL63 and MHV replication in vitro.
| Polymer | HCoV-NL63 | MHV | |
|---|---|---|---|
| IC LLC-MK2 (CPEa) | IC50 LLC-MK2 (qRT-PCRb) | IC50 LR7 (qRT-PCRb) | |
| HTCC | 10 μg/ml | 2.75 ± 1.18 μg/ml [13.41 nM] | 6.82 ± 1.16 μg/ml [33.27 nM] |
| HM-HTCC | 50 μg/ml | 68.52 ± 18.71 μg/ml [308.65 nM] | 72.33 ± 18.24 μg/ml [325.81 nM] |
Lowest compound concentration for which no CPE was noted.
50% inhibitory concentration as assessed by real-time RT-PCR analysis.
