Table 1.
Effects of plant extracts on SARS-CoV
| Plant extract | Family | Part used | Solvent | CC50a | Viral strain |
|||
|---|---|---|---|---|---|---|---|---|
| BJ-001 |
BJ-006 |
|||||||
| EC50b | SIc | EC50b | SIc | |||||
| Lycoris radiata | Amaryllis | Stem cortex | Ethanol | 886.6 (±35.0) | 2.4 (±0.2) | 370 | 2.1 (±0.2) | 422 |
| Artemisia annua | Compositae | Whole plant | Ethanol | 1053.0 (±92.8) | 34.5 (±2.6) | 31 | 39.2 (±4.1) | 27 |
| Pyrrosia lingua | Polypodiaceae | Leaf | Chloroform | 2378.0 (±87.3) | 43.2 (±14.1) | 55 | 40.5 (±3.7) | 59 |
| Lindera aggregate | Lauraceae | Root | Ethanol | 1374.0 (±39.0) | 88.2 (±7.7) | 16 | 80.6 (±5.2) | 17 |
| Interferon alpha | >100,000 (±710.1) | 660.3 (±119.1) | >151 | 587.2 (±39.0) | >170 | |||
Determined as the concentration of the compounds that reduced the cell viability to 50% of control (cells without addition of compound). Each represents the mean value from three independent experiments. The unit for CC50 values shown in the table is μg/ml except interferon alpha, which is IU/ml.
Determined as the concentration of the compounds needed to inhibit CPE to 50% of control value (cells without viral infection). Each represents the mean value from three independent experiments. The unit for EC50 values shown in the table is μg/ml except interferon alpha, which is IU/ml.
Selectivity index (CC50/EC50).