Table 3.
Anti-HIV-1 activity of the test compounds (Fig. 4, Fig. 5) against mutant HIV-1 strains in CEM cell cultures (Anon, 2002)
| Compo-und | EC50a (μM) |
||||
|---|---|---|---|---|---|
| HIV-1 (IIIB)b | Leu-100-Ileb | Lys-103-Asnb | Tyr-181-Cysb | Tyr-188-Hisb | |
| 15 | 5.5 | ND | 11 | 10 | ND |
| 16 | 7.5 | 12.5 | 9.0 | 10 | 12.5 |
| 17 | 6.0 | 11.5 | 8.5 | 7.5 | 11.0 |
| 18 | 2.8 | 6.0 | 7.0 | 10 | 7.5 |
| 19 | 2.8 | 5.3 | 6.0 | 8.5 | 6.0 |
a
Effective concentration or concentration required to protect CEM cells against the cytopathicity of resistant HIV-1 strains by 50%.
b
Different types of the resistant HIV-1 strains.