Table 1.
Inhibitory effects of EBN extract treated with Pancreatin F on hemagglutination and infection of various influenza A viruses isolated from humans, ducks, and pigs
| Viruses | HAI (μg/ml) |
IC50 (μg/ml) |
||
|---|---|---|---|---|
| S1-Pan | S2-Pan | SI-Pan | S2-Pan | |
| Human strains | ||||
| A/PR/8/34 (H1N1) | 5 | 40 | 36 ± 6a | 182 ± 16 |
| A/Aichi/2/68 (H3N2) | 5 | 160 | 76 ± 9 | 464 ± 38 |
| A/HongKong/1/68 (H3N2) | 10 | 40 | 41 ± 8 | 260 ± 22 |
| A/Memphis/102/72 (H3N2) | 10 | 40 | NDb | ND |
| A/Tokyo/6/73 (H3N2) | 5 | 40 | ND | ND |
| A/Kumamoto/55/76 (H3N2) | 20 | 80 | ND | ND |
| A/Texas/1/77 (H3N2) | 5 | 80 | ND | ND |
| A/Yamanashi/2/77 (H3N2) | 5 | 40 | ND | ND |
| A/Bangkok/1/79 (H3N2) | 5 | 20 | ND | ND |
| A/Shizuoka/450/05 (H3N2) | 20 | 80 | 84 ± 12 | 232 ± 46 |
| A/Shizuoka/451/05 (H3N2) | 20 | 80 | 96 ± 10 | 244 ± 32 |
| Avian strains | ||||
| A/Dk/Alb/35/76 (H1N1) | 10 | 80 | 24 ± 6 | 156 ± 18 |
| A/Dk/HongKong/7/75 (H3N2) | 2.5 | 20 | 41 ± 4 | 124 ± 16 |
| A/Dk/HongKong/24/76 (H3N2) | 10 | 80 | 40 ± 6 | 246 ± 42 |
| A/Dk/Hokkaido/5/77 (H3N2) | 2.5 | 20 | ND | ND |
| A/Dk/Hokkaido/8/80 (H3N8) | 2.5 | 10 | 24 ± 5 | 98 ± 23 |
| A/Dk/HongKong/23/76 (H5N3) | 2.5 | 20 | 36 ± 8 | 142 ± 18 |
| Swine strains | ||||
| A/Sw/Iowa/15/30 (H1N1) | 2.5 | 10 | 10 ± 2 | 86 ± 8 |
| A/Sw/HongKong/126/82 (H3N2) | 2.5 | 40 | 10 ± 3 | 104 ± 12 |
a
The IC50 is the mean ± S.D. of three dependent experiments.
b
ND: Not detected.