Table 1. Effect of Different Amounts of Catalysts, Temperature, and Solvent (5 mL) in the Synthesis of N-Amino-2-pyridones.
entry | catalysts (mg) | temperature (°C) | solvent | time (min) | yield (%) |
---|---|---|---|---|---|
1 | 10 | reflux | H2O | 40 | 90 |
2 | 10 | reflux | EtOH | 60 | 72 |
3 | 10 | reflux | n-hexane | 90 | trace |
4 | 10 | reflux | CH3CN | 45 | 76 |
5 | 10 | 110 | toluene | 65 | 55 |
6 | 10 | 100 | solvent-free | 60 | 43 |
7 | 7 | 80 | H2O | 50 | 81 |
8 | 5 | reflux | H2O | 60 | 80 |
9 | 15 | reflux | H2O | 40 | 90 |
10 | 10 | 75 | H2O | 55 | 78 |
11 | 10 | 50 | H2O | 65 | 66 |
12 | 10 | r.t. | H2O | 85 | 35 |
13 | r.t. | H2O | 120 | trace |