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. 2020 Mar 20;5(12):6240–6249. doi: 10.1021/acsomega.9b02133

Table 1. Effect of Different Amounts of Catalysts, Temperature, and Solvent (5 mL) in the Synthesis of N-Amino-2-pyridones.

2.

entry catalysts (mg) temperature (°C) solvent time (min) yield (%)
1 10 reflux H2O 40 90
2 10 reflux EtOH 60 72
3 10 reflux n-hexane 90 trace
4 10 reflux CH3CN 45 76
5 10 110 toluene 65 55
6 10 100 solvent-free 60 43
7 7 80 H2O 50 81
8 5 reflux H2O 60 80
9 15 reflux H2O 40 90
10 10 75 H2O 55 78
11 10 50 H2O 65 66
12 10 r.t. H2O 85 35
13   r.t. H2O 120 trace