Table 2.
Effects of GSK983 on growth of cell lines immortalized by episomal EBV or integrated HTLV1.
| Cell line (virus) | Cell line growth |
Host primary cell | Host primary cell growth |
Selectivity index |
|
|---|---|---|---|---|---|
| K (nM)a ± S.E. | Imax, % ± S.E. | CC50 (nM) ± S.E. | Value ± S.E. | ||
| IM9 (EBV) | 16 ± 2 | 97 ± 1 | Activated B cell | >10,000 | >620 ± 80 |
| B-LCL 5/2/1 (EBV) | 14 ± 0.3 | 93 ± 1 | Activated B cell | >10,000 | >700 ± 15 |
| MT4 (HTLV1) | 7.5 ± 0.6 | 98 ± 2 | Activated CD4 T cell | 57,000 ± 6,100 | 7600 ± 1000 |
Calculations from the data in Fig. 4.
a
Since the values of Imax are close to 100%, K ∼ EC50.