. 2009 Jan 31;82(1):1–11. doi: 10.1016/j.antiviral.2008.12.015

Table 3.

Effects of GSK983 on growth of cell lines immortalized by episomal human papillomavirus.

Cell	HPV type	Host primary cell	Measurement	K (nM) ± S.E.	I_max, % ± S.E.	Selectivity index ± S.E.
W12-20850^a	16	HKC	DNA, hybrid capture	4.5 ± 0.3	96 ± 1	8,900 ± 2,700
W12-20850^a	16	HKC	Growth, MTS	11 ± 2	60 ± 7
W12-20850^a	16	HKC	Ratio, HPV DNA/MTS	4.9 ± 0.5	90 ± 2
W12-20850	16	HKC	HPV DNA, qPCR	3.3 ± 0.5	85 ± 2	12,000 ± 4,000
W12-20850	16	HKC	Growth, Actin DNA, qPCR	6 ± 0.4	60 ± 1
CIN612	31	HKC	HPV DNA, qPCR	2.4 ± 0.1	86 ± 1	16,600 ± 5,000
CIN612	31	HKC	Growth, MTS	2.8 ± 0.1	70 ± 1
HKC/HPV16	16	HKC	HPV DNA, qPCR	2.2 ± 0.2	89 ± 2	18,000 ± 5,600
HKC/HPV16	16	HKC	Growth, MTS	3.0 ± 0.4	59 ± 1
Human keratinocyte (HKC)^a	None	N/A	Growth, MTS	40,000 ± 11,800	∼100

Experimental design for all cell types was as described in the legend for Fig. 5. Values of K and I_max were calculated by fitting to Eq. (1).

Data shown in Fig. 5.