Table 1. Sequences of Cationic and Non-Ribosomally Synthesized Antibacterial and Hemolytic Peptidesa.
| peptide | sequence | net charge |
|---|---|---|
| Phd1 | ACPIFTKIQGTYRGKAKCK | +5 |
| Phd2 | FCPRRYKQIGTGLPGTKCK | +5 |
| Phd3 | SCLPKEEQIGKSTRGRKCRRKK | +7 |
| MPhd1 | Myr-ACPIFTKIQGTYRGKAKCK | +4 |
| MPhd2 | Myr-FCPRRYKQIGTGLPGTKCK | +4 |
| MPhd3 | Myr-SCLPKEEQIGKSTRGRKCRRKK | +6 |
| melittin | GIGAVLKVLTTGLPALISWIKRKRQQ-CONH2 | +5 |
| LL37 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | +5 |
| alamethicin | acetyl-UPUAUAQUVUGLUPVUUEQFol | |
| gramicidin A | formyl-VGALAVVVWLWLWLWG–CH2–CH2–OH | |
| gramicidin S | cyclic (LOVPFdLOVPFd) | +2 |
| polymyxin B | cyclized isooctanoyl BTBB(BFdLBBT) |
a
Bold underline indicates disulfide bond. Net charge is at neutral pH. Superscript d after the amino acid represents the d-enantiomer; all other amino acids are L-form. Parentheses indicate amino acids that are cyclized. O, ornithine; B, diaminobutyrate; U, α-aminoisobutyric acid; Fol, phenylalaninol. Peptides Phd1-3, MPhd1-3 and LL37 have COOH at the C-terminus. LL37 sequence was taken from ref (3). The sequences of melittin, alamethicin and gramicidin A were taken from ref (32) gramicidin S and polymyxin B were taken from ref (37).