Table 2.
Antiviral activity of various compounds against porcine epidemic diarrhea virus in Vero cells.
| Test drugs | IC50a | CC50b | TIc | |
|---|---|---|---|---|
| Antiviral drugs | Ribavirin | 4.1 ± 4.2 | 423.3 | 103.2 |
| Interferon-α | 0.52 ± 0.5 unit | >100 unit | >192.3 | |
| Natural compounds | Coumarin | 47.4 | 229.3 | 4.8 |
| Tannic acid | 9 | 83.3 | 9.2 | |
| Flavonoids | Quercetin | 1.7 ± 0.8 | 365.2 | 214.8 |
| Apigenin | 0.1 ± 0.1 | >50 | >370.4 | |
| Luteolin | 0.2 ± 0.2 | 6.7 | 32.7 | |
| Catechin | 11.1 ± 7.1 | >100 | >9.0 | |
| Quercetin 7-rhanmoside | 0.014 ± 0.005 | >100 | >7142.86 | |
Results are presented as the mean IC50 values obtained from three independent experiments carried out in triplicate ± S.D.
a
Concentration required to inhibit virus-induced CPE by 50% (μg/mL).
b
Concentration required to reduce cell growth by 50% (μg/mL).
c
Therapeutic index = CC50/IC50.