Table 2.
Vancomycin and eremomycin type glycopeptides and their derivatives substituted in the Z position 
| LCTA | Code no. | Z | HIV-1 (CEM) |
FIPV (CRFK) |
SARS-CoV (Vero) |
|||
|---|---|---|---|---|---|---|---|---|
| EC50 (μM) | IC50 (μM) | EC50 (μM) | CC50 (μM) | EC50 (μM) | CC50 (μM) | |||
| Vancomycin (Van) and its derivatives W = Cl, S1 = Glc, S2 = vancosamine, S3 = H | ||||||||
| 222 | 46 | NO | NTa | NT | >80 | >80 | >80 | >80 |
| Eremomycin (Ere) and its derivatives W = H, S1 = Glc, S2 = S3 = eremosamine | ||||||||
| 147 | 47 | (CH3)2 | NT | NT | >80 | >80 | >80 | >80 |
| 182 | 48 | (CH2CHCH2)2 | NT | NT | >80 | >80 | >80 | >80 |
| 246 | 49 | Cbz | NT | NT | >80 | >80 | >80 | >80 |
a
NT, not tested.