Table 2.
Summary of current enzymatic and structural data of the alphavirus proteins nsP1, nsP2, nsP3 and nsP4.
| nsP1 | nsP2 | nsP3 | nsP4 | |||
|---|---|---|---|---|---|---|
| Domain | MTase/GTase | NTPase/helicase | Protease | Macro domain/ADPribosePPase | Cter domain | RdRp/TATase |
| Structural data | Yes (partly) (Spuul et al., 2007) | No | Yes (Russo et al., 2006) | Yes (Malet et al., 2009) | No | No |
| Enzymatic data | Yes/(partly) (Ahola and Kääriäinen, 1995) | Yes/yes (Rikkonen et al., 1994) | Yes (Vasiljeva et al., 2001) | Yes (partly) (Malet et al., 2009) | No | Yes (Lemm et al., 1994, Rubak et al., 2009, Tomar et al., 2006) |
| Inhibition data | Yes (Lampio et al., 1999) | No | Yes (Pastorino et al., 2008) | No | No | No |