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. 2013 Sep 12;112(3):338–347. doi: 10.1016/j.prevetmed.2013.09.001

Table 2.

Fecal zinc, serum zinc, and liver zinc, copper, and iron, concentrations expressed as means in neonatal Holstein calves before and after treatment with placebo, zinc methionine (Met), or zinc oxide (ZO) from a double-blind block-randomized clinical trial on the effects of zinc as a treatment for diarrhea.

Samplec Pre/Post N Treatmentsa, b
Placebo
 Zinc Met
 ZO
Mean SEM 95% C.I. Mean SEM 95% C.I. Mean SEM 95% CI
Lower Upper
Fecal zinc Pre 71 135.9 A 17.0 100.9 171.0 153.6 A 21.9 108.5 198.8 153.0 A 14.1 123.6 182.3
Post 71 378.4 A 48.2 278.4 478.5 1128.9 B 255.5 601.5 1656.3 651.3 AB 53.4 540.5 762.0
Serum zinc Pre 71 0.95 A 0.04 0.87 1.03 0.91 A 0.04 0.82 1.00 0.91 A 0.07 0.76 1.05
Post 71 1.09 A 0.05 0.99 1.19 1.28 B 0.05 1.18 1.39 1.16 AB 0.05 1.05 1.26
Liver zincd Pre 71 710.6 A 147.7 405.2 1016.1 852.3 A 129.6 585.4 1119.1 750.7 A 202.9 327.5 1173.9
Post 68 728.9 A 182.9 349.6 1108.3 1141.0 A 423.8 264.2 2017.7 636.8 A 81.5 466.9 806.8
Liver copper Pre 73 483.9 A 51.3 378.1 589.8 500.4 A 68.9 358.6 642.3 477.3 A 59.8 353.0 601.6
Post 70 683.0 A 119.7 435.3 930.7 741.7 A 211.5 304.2 1179.1 468.1 A 63.5 336.1 600.0
Liver irond Pre 71 381.7 A 72.4 232.2 531.2 363.3 A 65.9 227.6 499.1 205.9 A 33.3 136.3 275.5
Post 68 347.3 A 90.6 159.9 534.6 254.1 A 46.5 157.9 350.3 157.7 A 24.4 106.7 208.8
a

Treatments: Placebo = zinc-free oral rehydration solution (ORS); zinc Met = 80 mg of zinc/2 L of ORS (381.5 mg of zinc Met); ZO = 80 mg of zinc/2 L of ORS (99.7 mg of ZO).

b

Means with different letters within each row are significantly different (P < 0.05).

c

Fecal zinc (mg/kg of DW), serum zinc (mg/L), and liver zinc, copper, and iron (mg/kg of DW).

d

Liver zinc and iron concentration pre and post treatment: liver biopsy samples were insufficient for accurate zinc or iron determination in two samples. Thus, two calves had to be excluded from liver zinc and iron enrollment and exit analysis.