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Effects of single i.p. administration of high concentrations of ribavirin on SARS-CoV (Urbani) replication in 8–14 g female BALB/c mice
| Treatmenta (mg/kg) | Virus titer (log10 CCID50/g)b | Percent body weight change |
|---|---|---|
| Virus-infected mice | ||
| 175 | 4.6 ± 0.4 | +10 |
| 75 | 4.5 ± 0.3 | +40 |
| Placebo | 4.4 ± 0.4 | +9 |
| Uninfected mice | ||
| 175 | 0 | +4 |
| 75 | 0 | −7 |
| Placebo | 0 | +18 |
Animals were sacrificed on day 3. No virus was detected on day 7 in any animal.
Values are expressed as mean ± standard deviation.
