Table 1.
Effect of IFN-alpha-2a on Orthobunyavirus replication in Vero E6 cell culture
| Viruses | Treatment of the cells (h)a |
||||
|---|---|---|---|---|---|
| −24 | +2 | +24 | +48 | +72 | |
| Percentage of inhibition on plaque formationb (%) | |||||
| OROV | 99c | 99c | 0 | 0 | – |
| CARV | 100 | 100 | 65 | 0 | 0 |
| GMAV | 100 | 100 | 91e | 0 | – |
| GROV | 100 | 100 | 68 | 0 | 0 |
| TCMV | 100 | 99c | 94d | 72e | 40 |
a
Treatment was initiated before (−) or after (+) cell infection.
b
Percentage of inhibition on plaque formation by viruses in Vero E6 cells treated with 100,000 IU mL−1 of IFN-alpha-2a.
c
Statistical test: analysis of variance, followed by the parametric Tukey–Kramer test, p < 0.0005.
d
Statistical test: analysis of variance, followed by the parametric Tukey–Kramer test, p < 0.001.
e
Statistical test: analysis of variance, followed by the parametric Tukey–Kramer test, p < 0.01.