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Effect of the administration of IFN-alphaA initiated 24 h before mice infection (i.p.) with distinct Orthobunyavirus
| Viruses | Survived/total (percent survival) |
MTDa ± S.D. (days) |
||
|---|---|---|---|---|
| Placebo | IFN-αA | Placebo | IFN-αA | |
| OROV | 0/16 | 16/16 (100%)b | 8.5 ± 3.5 | >20 |
| CARV | 2/16 (12%) | 6/16 (37%) | 8.0 ± 2.8 | 9.0 ± 2.8 |
| GMAV | 0/16 | 0/16 | 6.0 ± 0 | 9.5 ± 3.5 |
| GROV | 0/16 | 16/16 (100%)b | 6.0 ± 0 | >20 |
| TCMV | 0/16 | 0/16 | 6.5 ± 3.5 | 10.0 ± 2.8 |
Mean time to death.
p < 0.001; Fisher's Exact test.
