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Effect of the administration of IFN-αA initiated 3 or 24 h after mice infection (i.p.) with OROV or GROV
| Treatment (after infection) | Viruses | Survived/total (percent survival) |
MTDa ± S.D. (days) |
||
|---|---|---|---|---|---|
| Placebo | IFN-αA | Placebo | IFN-αA | ||
| 3 h | OROV | 1/9(11%) | 3/9 (33%) | 5.0 ± 2.8 | 6.5 ± 2.1 |
| GROV | 0/9 | 8/9 (88%)b | 6.5 ± 2.1 | >20 | |
| 24 h | GROV | 0/9 | 2/9 (22%) | 7.0 ± 2.8 | 7.0 ± 2.8 |
Mean time to death.
p < 0.001; Fisher's Exact test.
