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. 2012 Feb 14;94(1):80–88. doi: 10.1016/j.antiviral.2012.02.004

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Copyright © 2012 Elsevier B.V. Published by Elsevier B.V. All rights reserved.

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Fig. 3 — Accommodation of sequence mismatches by PMOplus^TM therapeutics. Sequences represent an alignment of a generalized MARV consensus genome with the PMOplus^TM molecules comprising AVI-6003. Positively charged piperazine groups (+) and inosine bases (I) are positioned in the molecules at sites where mismatches occur. Genomic sequences from representative MARV variants/isolates are shown as cDNA complementary to genomic RNA. The MARV isolates shown include those against which AVI-6003 has exhibited antiviral activity in in vivo models (mouse-adapted Ravn virus, guinea-pig adapted MARV-Musoke, and non-adapted MARV-Musoke), or which were isolated during outbreaks (Ang0998, 07DRC, 09DRC), or which may have been involved in weaponization programs (Poppinga).