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Mechanism of action of S-adenosylhomocysteine hydrolase (SAH) inhibitors. SAH is a product-inhibitor of methylation reactions including those that are required for the maturation (5′-capping) of viral mRNAs. Through the hydrolysis of SAH, SAH hydrolase prevents the accumulation of SAH that would otherwise lead to inhibition of the SAM-dependent methylation reaction.
