Fig. 2.

Identification of drugs targeting dopamine and estrogen receptors as putative TPC2 inhibitors.

A, Venn diagram depicting the relationship between approved drugs identified as Ebola virus entry inhibitors in independent high through put screens by Kouznetsova [58] and Johansen et al. [59].

B, Venn diagram depicting the relationships between the entry inhibitors identified in A with the e-Drugs3D database used for the TPC virtual screen.

C, Venn diagram depicting the relationship between entry inhibitors present in the e-Drugs3-D database and the top 200 hits from the TPC virtual screen.

D, prioritised set of 14 drugs identified from C listing their rank in the TPC virtual screen, their reported IC₅₀ values for inhibiting virus entry (from Kouznetsova [58] and/or ^aJohansen et al. [59]) and their primary target (annotated in e-Drugs3D).