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. 2014 Nov 24;196:113–121. doi: 10.1016/j.virusres.2014.11.018

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© 2014 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 3 — Co-stimulatory effects of VP1 and IRFs on activation of the Atlantic salmon IFNa1 promoter. TO-cells were co-transfected with a plasmid containing the minimal IFNa1 promoter fused to a luciferase gene along with an expression construct for Renilla luciferase as a transfection control. In addition, expression constructs for IRF1 or IRF3, VP1, and VP1 in combination with IRF1 or IRF3 were included. Results are presented as mean relative light units (RLU) ± SD (N = 3). (A) Effects of IRF1, VP1, a combination of VP1 and IRF1 and vector control. IRF1 + VP1 is significantly different from VP1 and IRF1 (p < 0.05). (B) Effects of IRF3, VP1, a combination of VP1 and IRF3 and a vector control. IRF3 + VP1 is significantly different from VP1 and IRF3 (p < 0.05). All groups are different from vector control in A and B (p < 0.05).