. 2010 Jan 21;149(1):86–94. doi: 10.1016/j.virusres.2010.01.006

Table 5.

Experiment 4: histopathology scores^a in broiler chickens challenged with IBV at various times after treatment with QR448(a) at 1 day of age.

Treatment group	Challenge^b times post-treatment
	2 h	4 h	6 h	12 h	1 day	2 days	4 days	7 days
QR448(a) + IBV	2.07^D	2.18^D	2.08^D	2.11^D	1.85^D	2.10^D	2.00^D	2.10^D
QR448(a)	1.00^E	1.31^E	1.00^E	1.00^E	1.00^E	1.07^E	1.00^E	1.00^E
IBV	3.00^ABC	2.67^C	2.78^BC	2.67^C	2.70^C	3.09^AB	3.00^ABC	3.17^A
Negative control	1.00^E				1.00^E	1.00^E	1.07^E	1.00^E

Birds were necropsied at 5 days post-challenge, and tracheas were collected in 10% neutral buffered formalin and routinely processed and stained (see Section 2), then scored for epithelial hyperplasia, lymphocyte infiltration, and epithelial deciliation with 1 being normal and 4 being severe. Scores with different capital letter superscripts are statistically significant, Kruskal–Wallis test (p ≤ 0.01).

Birds that received challenge virus were given 1 × 10^3.5 EID₅₀ of the Mass41 strain of IBV intranasally.