Table 2.
Frequencies of IL28B rs12979860 and rs8099917 SNP in 138 infants hospitalized for bronchiolitis.
| Gender* |
Gestational age (weeks) | Birth weight (kg) | Age at hospital admission (days) | Weight at hospital admission (kg) | Severity of bronchiolitis** |
Fever | Days in hospital (days) | CRP (mg/dl) | Neutrophils (cells/μl) | Lymphocytes (cells/μl) | Eosinophils (cells/μl) | Platelets (n̊/μl) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | Group 0–1 | Group 2–3 | ||||||||||||
| IL28B rs12979860 | |||||||||||||||
| CC | 29 | 23 | 38.7 (0.2) | 3.3 (0.1) | 73.2 (6.9) | 5.3 (0.2) | 42 | 10 | 14 | 5.5 (0.4) | 1.5 (0.4) | 4019.9 (374.8) | 4882.2 (281.1) | 86.7 (17.3) | 476921.6 (24713.9) |
| CT + TT | 40 | 46 | 38.6 (0.2) | 3.1 (0.1) | 55.9 (3.6) | 4.7 (0.1) | 58 | 23 | 30 | 5.7 (0.3) | 1.2 (0.2) | 4104.3 (322.4) | 5037.1 (293.4) | 115.3 (13.9) | 446679 (17282.5) |
| p-value | 0.297 | 0.609 | 0.068 | 0.029 | 0.008 | 0.241 | 0.329 | 0.682 | 0.515 | 0.868 | 0.723 | 0.203 | 0.304 | ||
| TT | 5 | 9 | 39.1 (0.4) | 3.2 (0.1) | 45.7 (4.9) | 4.5 (0.3) | 10 | 4 | 7 | 6.1 (0.4) | 1.1 (0.4) | 4194.5 (915.3) | 4511.4 (765.2) | 128.1 (26.2) | 508769.2 (44466.8) |
| CT + CC | 64 | 60 | 38.6 (0.2) | 3.1 (0.1) | 64.4 (3.8) | 4.9 (0.1) | 90 | 29 | 37 | 5.5 (0.2) | 1.4 (0.2) | 4058.3 (253.1) | 5032.6 (218.4) | 101.8 (11.7) | 452857.1 (15040.4) |
| p-value | 0.277 | 0.326 | 0.773 | 0.005 | 0.197 | 0.719 | 0.165 | 0.391 | 0.734 | 0.866 | 0.453 | 0.461 | 0.245 | ||
| IL28B rs8099917 | |||||||||||||||
| GG | 2 | 2 | 39.3 (0.5) | 2.7 (0.2) | 50 (12) | 4.1 (0.5) | 3 | 1 | 2 | 6.3 (1.1) | 1.6 (1.1) | 2888.8 (550.1) | 5228.3 (2522) | 212.4 (36.9) | 386500 (61582.6) |
| GT + TT | 67 | 67 | 38.6 (0.2) | 3.2 (0) | 62.8 (3.6) | 4.9 (0.1) | 97 | 32 | 42 | 5.6 (0.2) | 1.3 (0.2) | 4108.5 (251.1) | 4970.9 (206.4) | 101.2 (11.0) | 460609 (14578.1) |
| p-value | 1.00 | 0.48 | 0.17 | 0.54 | 0.22 | 1.00 | 0.60 | 0.60 | 0.80 | 0.40 | 0.84 | 0.08 | 0.38 | ||
| TT | 48 | 38 | 38.6 (0.2) | 3.2 (0.1) | 63.9 (4.8) | 4.9 (0.1) | 66 | 20 | 26 | 5.6 (0.3) | 1.4 (0.3) | 3794.3 (264.9) | 4830.5 (218.3) | 101.4 (14.2) | 463141.2 (17741.6) |
| GT + GG | 21 | 31 | 38.6 (0.3) | 3.1 (0.1) | 60.1 (4.6) | 4.8 (0.2) | 34 | 13 | 18 | 5.5 (0.4) | 1.2 (0.3) | 4545.2 (480.0) | 5230.2 (432.0) | 109.6 (16.8) | 449723.4 (24224.2) |
| p-value | 0.11 | 0.95 | 0.76 | 0.61 | 0.72 | 0.67 | 0.57 | 0.82 | 0.72 | 0.14 | 0.36 | 0.72 | 0.65 | ||
*
The number of patients of each gender are shown and for other variables the means are shown with SE in parentheses. Chi square and t-test were used to compare respectively the categorical and the continuous outcome between patient group.
**
Infants were grouped according to the worst severity of bronchiolitis as previously described (Papoff et al., 2011). Significant correlations are highlighted in boldface.