Table 3.
List of genes that are over-expressed (mean expression level ≥1.5) in SARS-CoV infected lung tissue samples. All real-time qPCR results were expressed as fold changes in mRNA expression of patient samples with respect to the control samples and were normalized to the expression of the housekeeping gene β-actin.
| No. | Over-expressed gene | Mean expression level for early stage | Mean expression level for late stage |
|---|---|---|---|
| 1 | BPI | 159.68 | 11557.50 |
| 2 | ACE2 | 387.16 | 2805.44 |
| 3 | TAC1 | 1.04 | 765.88 |
| 4 | CASP3 | 18.49 | 520.09 |
| 5 | CEACAM8 | 13.67 | 274.43 |
| 6 | DEFA4 | 41.77 | 147.51 |
| 7 | IL10 | 9.37 | 121.10 |
| 8 | CCL3 | 7.84 | 76.59 |
| 9 | S100A8 | 2.38 | 73.41 |
| 10 | HLA-A | 1.22 | 60.59 |
| 11 | PPBP | 4.53 | 57.73 |
| 12 | CCL27 | 1.00 | 49.40 |
| 13 | LILRA3 | 6.50 | 43.80 |
| 14 | MICB | 16.79 | 38.89 |
| 15 | ANPEP | 2.74 | 36.04 |
| 16 | MNDA | 0.60 | 34.09 |
| 17 | USP | 8.94 | 32.79 |
| 18 | ITGAM | 4.88 | 32.36 |
| 19 | CXCL9 | 49.52 | 30.22 |
| 20 | IL1B | 2.25 | 29.50 |
| 21 | C1QB | 4.68 | 28.38 |
| 22 | ICAM1 | 4.56 | 26.57 |
| 23 | MAD | 10.93 | 26.33 |
| 24 | CD69 | 1.96 | 25.76 |
| 25 | CXCL10 | 164.93 | 25.57 |
| 26 | IMPA2 | 4.50 | 24.09 |
| 27 | IL1R1 | 3.22 | 21.94 |
| 28 | GBP | 132.93 | 21.58 |
| 29 | CD68 | 1.31 | 18.48 |
| 30 | EDN1 | 16.08 | 16.99 |
| 31 | IL8 | 0.55 | 16.50 |
| 32 | CSF2RA | 0.45 | 16.47 |
| 33 | CREBBP | 5.98 | 16.35 |
| 34 | FGF7 | 3.28 | 16.23 |
| 35 | SMAD | 8.83 | 15.34 |
| 36 | MSR1 | 2.46 | 15.21 |
| 37 | IL6 | 4.59 | 14.71 |
| 38 | CD22 | 1.36 | 14.65 |
| 39 | PECAM1 | 2.60 | 14.10 |
| 40 | MALAT-1 | 4.15 | 12.27 |
| 41 | BCAP29 | 7.14 | 11.87 |
| 42 | ITGA2B | 152.46 | 11.65 |
| 43 | LILRA2 | 5.12 | 11.53 |
| 44 | RAB31 | 1.32 | 11.13 |
| 45 | B2M | 5.28 | 10.93 |
| 46 | AREG | 2.17 | 9.79 |
| 47 | RPGR | 3.33 | 9.47 |
| 48 | IFNA6 | 2.36 | 8.92 |
| 49 | NFIL3 | 1.50 | 8.36 |
| 50 | CD4 | 0.87 | 8.31 |
| 51 | LTB4R | 2.93 | 8.27 |
| 52 | CCL28 | 4.10 | 8.14 |
| 53 | VEGF | 3.05 | 8.13 |
| 54 | CXCL2 | 0.90 | 7.76 |
| 55 | NFKBIA | 2.93 | 7.57 |
| 56 | IGF1 | 0.72 | 7.16 |
| 58 | ATP1B1 | 1.74 | 7.06 |
| 59 | NCF1 | 2.24 | 6.87 |
| 60 | CASP9 | 0.33 | 6.75 |
| 61 | KIAA0720 | 2.06 | 6.74 |
| 62 | IRF3 | 0.73 | 6.71 |
| 63 | CD14 | 0.83 | 6.70 |
| 64 | TFPI | 3.90 | 6.53 |
| 65 | DTR | 4.82 | 6.52 |
| 66 | CD9 | 1.43 | 5.59 |
| 67 | C4B | 2.60 | 5.37 |
| 68 | HIST2H2AA | 2.69 | 5.06 |
| 69 | SLPI | 0.49 | 4.32 |
| 70 | TNFSF5 | 1.73 | 4.00 |
| 71 | CSF1 | 2.91 | 3.97 |
| 72 | C3AR1 | 1.43 | 3.92 |
| 73 | LTB | 1.12 | 3.86 |
| 74 | HLA-DRA | 0.73 | 3.71 |
| 75 | PTAFR | 1.12 | 3.60 |
| 76 | STAT1 | 9.86 | 3.43 |
| 77 | ICAM2 | 1.84 | 3.41 |
| 78 | C5R1 | 0.29 | 3.36 |
| 79 | PIK3CB | 1.65 | 3.33 |
| 80 | TLR2 | 0.29 | 2.98 |
| 81 | CD3Z | 3.02 | 2.86 |
| 82 | EGR1 | 0.94 | 2.72 |
| 83 | CD8A | 0.74 | 2.39 |
| 84 | CCL2 | 2.16 | 2.31 |
| 85 | TNFRSF1A | 0.78 | 2.25 |
| 87 | NR2F2 | 1.28 | 2.10 |
| 86 | EGR2 | 1.22 | 2.10 |
| 88 | IFNB1 | 0.82 | 1.75 |
| 89 | IFNA1 | 2.08 | 1.52 |
| 90 | HP | 0.14 | 1.51 |
| 91 | IFNG | 1.74 | 1.05 |
| 92 | CLC | 12.29 | 1.00 |