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. 2020 Feb 13;28(2):137–149. doi: 10.4250/jcvi.2019.0111

Table 6. Cox regression analysis for LV reverse remodeling.

Variables Univariate analysis Multivariate analysis
HR 95% CI p-value HR 95% CI p-value
Age 0.993 0.973–1.013 0.465 1.000 0.974–1.026 0.974
Female sex 1.054 0.567–1.959 0.869 0.859 0.380–1.944 0.716
LBBB 5.066 1.567–16.376 0.007 1.808 0.519–6.300 0.352
ACE-I/ARBs 1.686 0.586–4.849 0.332 4.031 1.155–14.075 0.029
β-Blockers 1.285 0.188–1.927 0.337 1.692 0.839–3.697 0.173
Ivabradine 0.579 0.290–1.159 0.123 1.328 0.147–1.733 0.107
MRA 1.273 0.705–2.297 0.423 1.607 0.869–3.196 0.136
LVEDDI 0.994 0.948–1.042 0.798 1.329 0.985–1.792 0.062
LVESDI 0.993 0.944–1.045 0.782 0.689 0.494–0.960 0.028
LVEF 0.972 0.928–1.018 0.227 1.058 0.983–1.240 0.178
LV GLS 1.411 1.240–1.605 <0.001 1.474 1.170–1.856 0.001
LA volume index 0.918 0.880–0.957 <0.001 0.966 0.922–1.012 0.143
E/e′ ratio 0.921 0.874–0.971 0.002 0.958 0.890–1.031 0.255
Significant MR 0.851 0.466–1.551 0.598
RV FWLS 1.002 0.959–1.048 0.919

ACE-I: angiotensin-converting enzyme-inhibitor, ARB: angiotensin II receptor blocker, CI: confidence interval, GLS: global longitudinal strain, HR: hazard ratio, LA: left atrium, LBBB: left bundle branch block, LV: left ventricular, LVEDDI: LV end-diastolic diameter index, LVEF: LV ejection fraction, LVESDI: LV end-systolic diameter index, MR: mitral regurgitation, MRA: mineralocorticoid receptor antagonist, RV: right ventricular, RV FWLS: RV free-wall longitudinal strain.