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Free energy landscape of the C-DENR semi-extended conformation. S denotes the starting crystal structure, I-1 and I-2 are the intermediate states and G is the compact ground state. The two collective variables are: β-sheet, β-strand character of the N-terminal residue stretch 121–133 of the C-DENR110–195 mutant; d-COM, the distance of the center of mass of these residues with the rest of the molecule.
