Table 2.

Objectives of individual cat infection experiments.

Expt.	Inoculum	Objective
1A, 1B	FECV-1	To determine the infectivity of FECV and fecal shedding status by different routes (i.p. and oronasal).
2	FCov-2	To determine whether the fecal coronavirus shed by naturally occurred FIP cat can induce FIP in experimental cats by oronasal route.
3A, 3B	i3c-1, m3c-1	To confirm that both of the FIPV isolates containing either intact 3c or mutate 3c genes can induce FIP in experimental cats.
4A	i3c-2	To determine whether cats with previous exposure will resist FIPV challenge.
4B	m3c-1	To determine whether the FIPV with a mutated 3c will cause enteric infection and FIP when given by oronasal route.
5A	i3c-2	To determine whether the FIPV with an intact 3c will cause enteric infection and FIP when given by oronasal route.
5B	m3c-2	To confirm that FIPV with a mutated 3c will induce FIP, but not to cause enteric infection when given i.p.
6A, 6B	i3c-2, m3c-2	To confirm whether the FIPV with an intact or mutated 3c will cause enteric infection and FIP when given by oronasal route.
7B, 8B	ddFIPV (tissue)	To determine whether the purified ddFIPV isolate can cause enteric infection and FIP in experimental cats.
9A, 10A	i3c-2 (feces)	To determine whether the fecal coronavirus shed by experimental FIP cats can induce enteric infection and FIP by i.p. or oronasal route.
9B, 10B	ddFIPV (feces)	To determine whether the fecal coronavirus shed by experimental FIP cats can cause enteric infection and FIP in experimental cats infected i.p. or oronasal.