Table 1.
Differences in the predicted amino acid sequences, virulence in cats, and cell proliferation between strain FIPV 79-1146 and mar mutant viruses.
| Virus | ORF 1ab | ORF 2 (S) |
ORF 3abc | ORF 4 (E) | ORF 5 (M) | ORF 6 (N) | ORF 7 |
Pathogenicity in cats | Proliferation of cells |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S1 | S2 | a | b | Monocyte | Macrophage | |||||||
| FIPV 79-1146 | * | * | * | * | * | * | * | * | * | High | High | High |
| mar 6-4-2.C2 | * | T → K (554)a,b | * | * | * | * | * | * | * | High | High | High |
| mar 7-4-1.C2 | * | A → V (480)a | * | * | * | * | * | * | * | High | High | High |
| R → C (647)a,b | ||||||||||||
| mar 6-4-2.7-4-1 | * | A → V (480)a | * | * | * | * | * | * | * | Moderate to low | Moderate to high | Moderate to low |
| T → K (554)a,b | ||||||||||||
| R → K (647)a,b | ||||||||||||
| mar 5-7-2.C1 | * | L → S (589)a,b | * | * | * | * | * | * | Deleted (N-terminal 29aa) | Low | High | High |
| mar 5-7-2.C2 | * | M → T (542)a,b | * | * | * | * | * | * | Deleted (N-terminal 29aa) | Low | Low | Low |
| L → S (589)a,b | ||||||||||||
| mar 5-7-2.7-4-1 | * | M → T (542)a,b | * | * | * | * | * | * | Deleted (N-terminal 29aa) | Low | Low | Low |
| L → S (589)a,b | ||||||||||||
| R → L (647)a,b | ||||||||||||
The predicted amino acid sequence conserved between strain FIPV 79-1146 and FIPV mar mutant virus indicated by asterisks.
These information were referred to the article by Kida et al. (1999).
Amino acids present in the neutralizing epitope (A1 and A2 sites) of FIPV 79-1146 (Corapi et al., 1995, Kida et al., 1999).