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. 2008 May 12;135(2):237–246. doi: 10.1016/j.virusres.2008.03.020

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Copyright © 2008 Elsevier B.V. All rights reserved.

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Fig. 3 — Illustration of conservation of the ORF-X amino acid sequence and the putative TRS found upstream of the ORF-X gene among a number of group III coronaviruses. TCoV and IBV share a highly conserved 94 amino acids hypothetical protein, designated as ORF-X. A highly conserved TRS motif (GTCAACAA) for ORF-X is found 288 nt upstream, within the M gene, in all group III coronaviruses. The Beaudette strain of IBV and strains derived from it such as IBV-p65 have a 49 nt deletion in ORF-X but the remaining sequence aligns unequivocally with all other group III coronaviruses when this deletion is taken into account. ¹n/a, no sequence available for this region; ²single nucleotide (A) from position 446 (AF072911.1) was deleted to maintain reading frame; ³17 amino acid deletion (51 nucleotides for 17 codons) in these sequences.