Skip to main content
. 2013 Sep 13;177(2):127–137. doi: 10.1016/j.virusres.2013.09.006

Table 1.

Overview of the IBV spike constructs and their characteristics.

Abbreviation Description Schematic outline Sequence aa 533–538 ProP score S1/S2 Sequence aa 686–691 ProP score 2nd
Beaudette full length spike protein graphic file with name fx1.gif RRFRR/S 0.779 SRRKR/S 0.833
M41 full length spike protein graphic file with name fx2.gif RRFRR/S 0.779 SPRRRS 0.331
B.S1 Beaudette S1 graphic file with name fx3.gif Not present × Not present ×
M.S1 M41 S1 graphic file with name fx4.gif Not present × Not present ×
B.ED Beaudette ectodomain graphic file with name fx5.gif GGGVPS 0 SRRKR/S 0.833
B.ED*cl Beaudette ectodomain; 2nd furin cleavage site knockout graphic file with name fx6.gif GGGVPS 0 SHRKHS 0.102
B.ED*M41 Beaudette ectodomain; 2nd cleavage site mutation M41 graphic file with name fx7.gif GGGVPS 0 SPRRRS 0.331
M.ED M41 ectodomain graphic file with name fx8.gif GGGVPS 0 SPRRRS 0.331
M.S1-B.S2*cl M41 S1 – Beaudette S2; 2nd furin cleavage site knockout graphic file with name fx9.gif GGGVPS 0 SHRKHS 0.102
B.S1-M.S2 Beaudette S1 – M41 S2 graphic file with name fx10.gif GGGVPS 0 SPRRRS 0.331

Sequences with ProP scores less than 0.5 are considered not to be cleaved by furin.

/ indicates site of furin cleavage.