Table 1.
Summary of clinical signs and fecal virus RNA shedding in gnotobiotic (Gn) or conventional pigs experimentally inoculated with US porcine deltacoronavirus (PDCoV).
| Pig, age (days) at inoculation | PDCoV strain, oral inoculation dose | Onset of diarrhea (PIH or PID)b | Onset of fecal virus shedding (PIH or PID)b | Peak viral RNA titer in feces (gram) or rectal swab fluids (ml) | Duration of diarrhea (days) | Duration of fecal virus shedding | Reference |
|---|---|---|---|---|---|---|---|
| Gn, 14 | Wild-type OH-FD22 or OH–FD100, 8.8–11.0 log10 GE/piga | PIH 21-24 | PIH 21-24 | NDc | 6 | PID 1 to 20 | Jung et al., 2015c, Hu et al., 2016 |
| Conventional, 5 | Cell culture-adapted USA/IL/2014 (P11), 3 × 104 TCID50/piga | PID 5 | PID 4 or 5 | NDc | NDc | NDc | Chen et al., 2015b |
| Gn, 10 | Cell culture-adapted Michigan/8977/2014 (P15), 106 PFU/piga | PID 3 | PID 1 or 2 | NDc | NDc | NDc | Ma et al., 2015 |
| Conventional, 10 | PID 1 | PID 1 or 2 | 6-7 log10 RNA copies/gram at PID 7 | 7–10 | PID 1 to 21 | ||
| Gn, 14 | Cell culture-adapted OH-FD22 at cell-culture passages 5 (P5), 20 (P20), and 40 (P40), 10.1–10.8 log10 GE/piga | PID 2 | PID 2 | 7.8–8.9 log10 GE/ml at PID 2 to 5 | 5–7 | PID 2 to 20 (for the strain OH-FD22 P20) | Hu et al., 2016 |
a
GE, genome equivalents; TCID50, 50% tissue culture infectious dose; PFU, plaque forming unit; P11 or P15, PDCoV cell-culture passages 11 or 15.
b
PIH, postinoculation hour; PID, postinoculation day.
c
ND, not determined.