Fig. 1.

Genome organization of the human norovirus. HuNoV genome organization, translation and processing. The VPg linked positive single-stranded RNA genome of HuNoV contains three open reading frames, ORF1, ORF2 and ORF3. The subgenomic RNA only contains ORF2 and ORF3. The ORF1 is translated by host translation machinery into a single polypeptide which then is proteolytically cleaved by the viral protease into six nonstructural proteins, named p48, NTPase, p22, VPg, Protease (Pro), and the RNA dependent RNA polymerase (RdRp). ORF2 and ORF3 are translated into the major and the minor capsid proteins, named VP1 and VP2, respectively. Currently available structures of norovirus proteins are illustrated under each named protein. VP1 PDB: 1IHM, RdRp PDB: 1SH0, protease PDB: 2FYQ.