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. 2016 Dec 29;234:21–33. doi: 10.1016/j.virusres.2016.12.018

Fig. 4.

Fig. 4

Mechanism of RNA replication by norovirus RdRp. (A) Norovirus RdRp recognizes the 3′ end of the viral RNA(+) genome (blue), and produces the negative-strand intermediate by de novo initiation of RNA synthesis (red). This RNA serves as template to recruit VPg as primer for synthesis of new RNA(+) copies of viral genomic RNA. Subgenomic RNA is also produced when norovirus RdRp recognizes a promoter sequence present on the downstream of the VP-1 gene on the negative-strand intermediate RNA. (B) Promoter sequence for human norovirus genome.