Table 1.
Summary of mutations in HVRs introduced into the Beaudette strain.
| Name | Amino acid sequences in the S1 subunit of spike proteina |
||
|---|---|---|---|
| HVR I (positions 50–86) | HVR II (positions 104–138) | HVR III (positions 272–291) | |
| Beaudette | VNISSEFNNAGSSSGCTVGIIHGGRVVNASSIAMTAP | FSDTTVFVTHCYKHGGCPITGMLQQNFIRVSAMKN | FIFHNETGANPNPSGVQNIQ |
| ck/CH/LDL/091022 | VNSTNYTSNAGSASECTVGVIKDVYNQSAASIAMTAP | FSEITVFVTHCYSSGTGSCPITGMIARDHIRISAMKN | FTFTNVSTAQPNSGGVSTFH |
| rHVR I | VNSTNYTSNAGSASECTVGVIKDVYNQSAASIAMTAP | FSDTTVFVTHCYKHGGCPITGMLQQNFIRVSAMKN | FIFHNETGANPNPSGVQNIQ |
| rHVR II | VNISSEFNNAGSSSGCTVGIIHGGRVVNASSIAMTAP | FSEITVFVTHCYSSGTGSCPITGMIARDHIRISAMKN | FIFHNETGANPNPSGVQNIQ |
| rHVR III | VNISSEFNNAGSSSGCTVGIIHGGRVVNASSIAMTAP | FSDTTVFVTHCYKHGGCPITGMLQQNFIRVSAMKN | FTFTNVSTAQPNSGGVSTFH |
| rHVR I/II | VNSTNYTSNAGSASECTVGVIKDVYNQSAASIAMTAP | FSEITVFVTHCYSSGTGSCPITGMIARDHIRISAMKN | FIFHNETGANPNPSGVQNIQ |
| rHVR I/III | VNSTNYTSNAGSASECTVGVIKDVYNQSAASIAMTAP | FSDTTVFVTHCYKHGGCPITGMLQQNFIRVSAMKN | FTFTNVSTAQPNSGGVSTFH |
| rHVR II/III | VNISSEFNNAGSSSGCTVGIIHGGRVVNASSIAMTAP | FSEITVFVTHCYSSGTGSCPITGMIARDHIRISAMKN | FTFTNVSTAQPNSGGVSTFH |
| rHVR I/II/III | VNSTNYTSNAGSASECTVGVIKDVYNQSAASIAMTAP | FSEITVFVTHCYSSGTGSCPITGMIARDHIRISAMKN | FTFTNVSTAQPNSGGVSTFH |
a
Substitutions of amino acids in HVRs are shown in bold for the ck/CH/LDL/091022 strain compared with those in the Beaudette strain.