Table 8.
Total WOMAC values before and after viscosupplementation.
| Study/Interval | Baseline |
Follow-Up |
p-value | ||
|---|---|---|---|---|---|
| Mean | SD | Mean | SD | ||
| 1-month | |||||
| Clementi et al. 201819 | |||||
| UHMW | 69.3 | 19.6 | 60.1 | 18.3 | – |
| MMW | 69.8 | 21 | 59.5 | 18.8 | – |
| Spitzer et al. 201051 | 64.27 | 1.27 | – | – | <0.0001 |
| Dıraçoğlu et al. 200939 | 17.26 | 2.49 | 12.27 | 2.40 | <0.001 |
| Tikiz et al. 200531 | 63.9 | 21.3 | 37.1 | 28.4 | <0.001 |
| 3-months | |||||
| Clementi et al. 201819 | |||||
| UHMW | 69.3 | 19.6 | 56.8 | 14.5 | – |
| MMW | 69.8 | 21 | 57.1 | 17.4 | – |
| Suppan et al. 201754 | 57.4 | 1.37* | 79 | 1.13* | <0.001 |
| Tikiz et al. 200531 | 63.9 | 21.3 | 43.6 | 31.4 | <0.001 |
| Conrozier et al. 200346 | 157.2 | 53.5 | 104 | 79.7 | <0.0001 |
| 6-months | |||||
| Clementi et al. 201819 | |||||
| UHMW | 69.3 | 19.6 | 56.5 | 14.5 | – |
| MMW | 69.8 | 21 | 57.1 | 17.4 | – |
| Tikiz et al. 200531 | 63.9 | 21.3 | 38.7 | 30.3 | <0.001 |
| Pourbagher et al.45 | 41.6 | 1.96 | 20 | 6.02 | <0.05 |
| 26-weeks | |||||
| Spitzer et al. 201051 | 64.27 | 1.27 | – | – | <0.0001 |
| 12-months | |||||
| Clementi et al. 201819 | |||||
| UHMW | 69.3 | 19.6 | 57.2 | 13.7 | – |
| MMW | 69.8 | 21 | 57.1 | 16 | – |
*Values reported as Standard Error of the Mean (SEM).
UHMW: Ultra High Molecular Weight; MMW: Medium Molecular Weight; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index; SD: standard deviation.