Table 2.

Infection type, treatment strategy, and outcomes.

Patient	Orthopaedic infection(s)	Date of positive GAS culture	Surgical management	Antibiotic Regimen	Total Antibiotic Duration	ID consult	Initial and final ESR mm/hr)	Initial and final CRP (mg/dL)	Cure at 90 days	Comments
1	Right leg necrotizing fasciitis, osteomyelitis; prior tibial ORIF	7/3/2017	I&D and fasciotomy	2 weeks of IV vancomycin/piperacillin-tazobactam/clindamycin or IV penicillin, then 4 weeks of PO amoxicillin/clavulanate	6 weeks	Y	110, 39	42.4, 3.7	Yes	IVIG X 3 days
2	Left hand flexor tenosynovitis	9/18/2018	I&D	IV Ceftriaxone and metronidazole for 4 days, then PO amoxicillin/clavulanate for 10 days	2 weeks	Y	55, not done	6.3, not done	Yes
3	Right hand flexor tenosynovitis	10/20/2018	I&D	IV Ampicillin/sulbactam for 3 days, then PO amoxicillin/clavulanate for 2 weeks	17 days	Y	101, 47	4.2, 0.8	Yes
4	Left foot necrotizing fasciitis and osteomyelitis	10/24/2018	I&D, below knee amputation	IV Vancomycin and piperacillin/tazobactam for 5 days, then IV ceftriaxone andclindamycin for 1 week, then PO linezolid for 17 days	4 weeks	Y	>140, >140	33.4, 9.7	No
5	Left foot osteomyelitis	10/18/2018	Foot amputation	PO Linezolid for 4 weeks	4 weeks	Y	46, not done	2.4, not done	No
6	Right foot osteomyelitis	11/30/2018	None	IV Vancomycin and piperacillin/tazobactam for 3 days	3 days	N	72, not done	1.8, not done	No	Patient left against medical advice; had co-infection with P. multocida
7	Right foot necrotizing fasciitis and osteomyelitis	11/24/2018	Foot amputation	IV Vancomycin and piperacillin/tazobactam for 4 days, then IV ceftriaxone and clindamycin for 3 days, then IV ampicillin/sulbactam for 2 weeks	3 weeks	Y	85, not done	30.8, not done	Yes	Co-infection with MSSA
8	Left hip and femur septic arthritis and osteomyelitis	12/30/2018	I&D	IV Vancomycin and ceftriaxone for 1 week, then PO cephalexin for 6 weeks	7 weeks	Y	40, not done	4.5, <0.5	Yes
9	Right ankle prosthetic joint infection	12/12/2018	I&D and prosthesis removal with antibiotic bead placement, followed by revision	IV Ceftriaxone and clindamycin for 1 week, then IV ceftriaxone alone for 5 weeks	6 weeks	Y	114, 41	17.3, 0.7	Yes
10	Right foot osteomyelitis	12/3/2018	Foot amputation	IV Vancomycin and ciprofloxacin for 5 days, then IV cefazolin for 1 week	12 days	Y	35, not done	3.5, not done	No	Co-infection with MSSA
11	Right leg necrotizing fasciitis and osteomyelitis	12/2/2018	Below knee amputation	IV Vancomycin, clindamycin and meropenem for 11 days	11 days prior to in-hospital death	Y	27, not done	31.2, not done	No	Co-infection with P.stuartii, deceased within 90 days from fungemia
12	Right knee prosthetic joint infection	2/19/2019	I&D, one-stage prosthesis revision	IV Ceftriaxone and clindamycin for 1 week, then IV ceftriaxone alone for 5 weeks, then PO cephalexin chronic suppression	6 weeks, then chronic suppression	Y	53, 28	3.4, 1.5	Yes	Suppressive cephalexin for ≥1 year due to immuno-suppressive therapy for RA
13	Right ankle achilles tenosynovitis overlying prior ORIF site	4/11/2019	I&D, antibiotic beads placement, followed by skin graft	Vancomycin and piperacillin/tazobactam for 3 days, then cefazolin for 3 days then linezolid for 2 weeks	3 weeks	Y	30, not done	0.9, not done	Yes	Co-infection with MSSA

IV: intravenous, PO: oral, ESR: erythrocyte sedimentation rate, I&D: incision and drainage, IVIG: intravenous immunoglobulin, MSSA: methicillin-susceptible S. aureus, RA: rheumatoid arthritis.