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. 2020 Mar 13;17:505–519. doi: 10.1016/j.omtm.2020.03.003

Figure 3.

Figure 3

Design of Short Promoters based on Human GRM6

(A) Genomic region upstream of the translation start site (TLSS) showing the two selected proximal promoter variants, 566P and 454P. (B) Distal genomic region showing the two selected enhancer elements, 407En and 770En. Shaded regions indicate high sequence conservation between the murine and human genomes. Sequence locations are given relative to the TLSS. Markers for regulatory elements: DNase I hypersensitivity clusters, H3K27 acetylation marks, sequence conservation across 100 vertebrates (100 Vert. Cons) and ChIP-Seq peaks. TSS, transcription start site. Images were downloaded from the University of California, Santa Cruz (UCSC), Genome Browser at https://genome.ucsc.edu/ and modified.