Table I.

Studies of ‘universal’ chlorhexidine daily bathing, with or without other interventions

Study	Setting	Design	Intervention	Results
Derde et al.22	ICU	Time-series analysis	Universal CHG plus hand hygiene	Reduction in all MDROs and MRSA (but not VRE or ESBLs)
Climo et al.23	ICU	Cluster RCT	Universal CHG	Reductions in MRSA/VRE acquisition and all BSI; BSI mainly CoNS
Milstone et al.24	Paediatric ICU	Cluster RCT	Universal CHG	BSI reduced; mainly CoNS
Huang et al.25	ICU	Cluster RCT	Universal CHG + mupirocin	Reduction in MRSA clinical isolates and all BSI; MRSA BSI not reduced

ICU, intensive care unit; CHG, chlorhexidine gluconate; MDROs, multidrug-resistant organisms; MRSA, meticillin-resistant Staphylococcus aureus; VRE, vancomycin-resistant enterococcus; ESBL, extended-spectrum beta-lactamase producer; RCT, randomized controlled trial; BSI, bloodstream infection; CoNS, coagulase-negative staphylococci.