Table II.

Studies of selective digestive decontamination (SDD) or selective oral decontamination (SOD)

Study	Setting	Design	Intervention	Results
de Jong et al.26	ICU	RCT	SDD	Mortality and acquisition of MDR-GNB reduced
de Smet et al.27	ICU	Cluster RCT	SDD or SOD	Both SOD and SDD reduced mortality
Oostdijk et al.28	ICU	Cluster RCT	SDD vs SOD	No significant difference in mortality, but SDD → more antibiotic resistance
Saidel-Odes et al.29	Adults	RCT	SDD	Reduced, but did not eliminate, CRE colonization

ICU, intensive care unit; RCT, randomized controlled trial; MDR-GNB, multidrug-resistant Gram-negative bacilli; CRE, carbapenem-resistant Enterobacteriaceae.