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. 2007 Apr 2;47(3):387–395. doi: 10.1016/j.jhep.2007.03.008

Fig. 1.

Fig. 1

Schematic representation of the role of ACE2 in the renin angiotensin system (RAS) showing the predominant pathway in solid lines for the generation of hypotensive and anti-fibrotic peptide angiotensin-(1–7) (Ang-(1–7)) from the substrate Ang I via Ang II, catalysed by angiotensin converting enzyme (ACE) and ACE2, and its degradation by ACE into inactive peptide Ang-(1–5). AT1 receptor, Ang II type 1 receptor.