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. 2007 Apr 2;47(3):387–395. doi: 10.1016/j.jhep.2007.03.008

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Copyright © 2007 European Association for the Study of the Liver. Published by Elsevier Ireland Ltd. All rights reserved.

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Fig. 5 — Plasma angiotensin converting enzyme (ACE) activity (a) and ACE2 activity (b) in sham-operated control (open bars) and bile duct ligated (BDL) (filled bars) rats. ACE and ACE2 activity were determined by measuring nmol of ACE substrate (Hippuryl-His-Leu) and pmol of ACE2 substrate (Mca-APK-(Dnp)-OH), respectively, cleaved by solubilized membrane fractions. Each bar represents the mean ± SEM activity from 9 to 10 rats per treatment group. ^∗∗∗∗P < 0.0005, ^∗P < 0.05, BDL vs. sham.