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. 2020 Mar 6;19(5):3369–3380. doi: 10.3892/ol.2020.11449

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Copyright: © Geng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Mechanisms for circRNA biogenesis. (A) RBP-mediated circularization. (B) Lariat-driven circularization. (C) Intron pairing-driven circularization. (D) ciRNAs are also generated via lariat-driven circularization. (E) Biogenesis of tricRNAs. circRNA, circular RNA; RBP, RNA-binding protein; ciRNA, circular intronic RNA; tricRNA, tRNA intronic circular RNA; ecircRNA, exonic circRNA; EIciRNA, exon-intron circRNA; tRNA, transfer RNA.