Table 3.
Association between race and major adverse cardiac events (MACE), adjusting for traditional risk factors for MACE and SNPs; results of Cox proportional hazard models with all participants and with data from only unrelated participantsc; ARIC, 1987–1989.
| All participants | N | HR (95% CI) | Variable (s) in model |
|---|---|---|---|
| Model 1 | 12770 | 1.46 (1.32,1.61)a | Race |
| Model 2 | 12751 | 1.55 (1.40,1.72)a | Model 1 + age, gender, and BMI |
| Model 3 | 12704 | 1.32 (1.18,1.47)a | Model 2 + alcohol use and cigarette use |
| Model 4 | 12512 | 1.19 (1.06,1.33)b | Model 3 + marital status and educational status |
| Model 5 | 12409 | 1.24 (1.10,1.39)a | Model 4 + current aspirin use |
| Model 6 | 12189 | 0.98 (0.87,1.11) | Model 5 + high cholesterol, diabetes, and hypertension |
| Only unrelated | |||
|
| |||
| Participants | N | HR (95% CI) | Variable (s) in model |
|
| |||
| Model 1 | 11843 | 1.42 (1.31,1.54)a | Race |
| Model 2 | 11825 | 1.55 (1.43,1.69)a | Model 1 + age, gender, and BMI |
| Model 3 | 11781 | 1.33 (1.22,1.45)a | Model 2 + alcohol use and cigarette use |
| Model 4 | 11601 | 1.19 (1.08,1.30)b | Model 3 + marital status and educational status |
| Model 5 | 11505 | 1.22 (1.11,1.34)a | Model 4 + current aspirin use |
| Model 6 | 11299 | 1.04 (0.95,1.6) | Model 5 + high cholesterol, diabetes, and hypertension |
Reference is the white race; ap < 0.001; bp < 0.05; cin cases of familial relatedness, only data from the first enrolled individual were used.