Table 1.
N = 25 | |||
---|---|---|---|
N | (%) | ||
Age (years) | |||
Median | 51 | ||
Range | 31–72 | ||
Preoperative serum CA-125 level (U/ml)* | |||
Median | 79.6 | ||
Range | 18.9–428.5 | ||
ECOG performance status | |||
0 | 16 | 64 | |
1 | 9 | 36 | |
FIGO stage | |||
I A | 4 | 16 | |
I C | 7 | 28 | |
II B | 2 | 8 | |
III A | 1 | 4 | |
III C | 10 | 40 | |
IV A | 1 | 4 | |
Primary tumor site | |||
Ovary | 21 | 84 | |
Peritoneum | 3 | 12 | |
Fallopian tube | 1 | 4 | |
Histology | |||
High-grade serous carcinoma | 12 | 48 | |
Endometrioid carcinoma | 5 | 20 | |
Clear cell carcinoma | 7 | 28 | |
Others** | 1 | 4 | |
Supra-renal PAN enlargement on CT*** | |||
Yes | 2 | 8 | |
No | 23 | 92 | |
Ascites at laparotomy | |||
Yes | 11 | 44 | |
No | 14 | 56 | |
Timing of surgery | |||
PDS or staging | 15 | 60 | |
NAC-IDS*** | 10 | 40 | |
Operative procedures | |||
TH+BSO | 25 | 100 | |
Omentectomy | 25 | 100 | |
Pelvic lymphadenectomy | 25 | 100 | |
Para-aortic lymphadenectomy | 25 | 100 | |
Pelvic peritoneum stripping | 10 | 40 | |
Abdominal peritoneum stripping | 11 | 44 | |
Recto-sigmoidectomy/anastomosis | 1 | 4 | |
Large bowel resection | 1 | 4 | |
Diaphragm stripping/resection | 8 | 32 | |
Splenectomy | 1 | 4 | |
Liver resection | 1 | 4 | |
Small bowel resection | 1 | 4 | |
Residual tumors | |||
No macroscopic residual tumor | 20 | 80 | |
Smaller than 1 cm in diameter | 5 | 20 | |
UICC TNM | |||
pT1 | 12 | 48 | |
pT2 | 2 | 8 | |
pT3 or ypT3 | 11 | 44 | |
No. of dissected lymph nodes | |||
PLN | |||
Median | 26 | ||
Range | 14–55 | ||
Infra-renal PAN | |||
Median | 21 | ||
Range | 12–36 | ||
Supra-renal PAN | |||
Median | 5 | ||
Range | 2–10 |
Abbreviations: CA-125 cancer antigen 125, NAC neoadjuvant chemotherapy, IDS interval debulking surgery, ECOG Eastern Cooperative Oncology Group, FIGO International Federation of Gynecology and Obstetrics, TH total hysterectomy, BSO bilateral salpingo-oophorectomy, UICC Union for International Cancer Control, PLN pelvic lymph nodes, PAN para-aortic lymph nodes
*Including data obtained just before IDS
**Serous carcinoma + endometrioid carcinoma
***Enlargement of supra-renal PAN was defined as at least one node ≥ 1 cm on CT before the start of treatment
***Debulking surgery was performed after 3–4 cycles of chemotherapy (platinum + taxane + bevacizumab)