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. 2020 Apr 2;19:71. doi: 10.1186/s12943-020-01179-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The function of circFNDC3B in CC cells. a Expression of circFNDC3B and FNDC3B mRNA in HCT116 cells transfected with overexpressing circFNDC3B, and b DLD1 cells with siRNA. c and d The effect of circFNDC3B on cell proliferation in vitro using CCK8 assay after upregulating or downregulating circFNDC3B in CC cells. e and f The effect of circFNDC3B on cell proliferation in vitro using colony formation assay after upregulating or downregulating circFNDC3B in CC cells. g and h Cell invasion abilities were assessed by transwell assay after upregulating or downregulating circFNDC3B in CC cells. i and j Cell migration abilities were assessed by wound-healing assay after upregulating or downregulating circFNDC3B in CC cells. **P < 0.01, ***P < 0.001