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. 2020 Apr 2;19:71. doi: 10.1186/s12943-020-01179-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — circFNDC3B-218aa promotes the tumor-suppressive effect of FBP1 in CC via inhibiting Snail. a The expression of levels of FBP1 and E-cadherin were inhibited by Snail, but this effect was restored by circFNDC3B-218aa presented in Western blot analysis. b The relative protein expression of Snail, FBP1, E-cadherin and vimentin as detected by Western blot analysis. c The invasion abilities enhanced by Snail were restored after co-transfection with circFNDC3B-218aa using transwell assay. d The invasion abilities enhanced by downregulated FBP1 were restored after co-transfection with circFNDC3B-218aa using transwell assay. e The migration abilities enhanced by Snail were restored after co-transfection with circFNDC3B-218aa using wound-healing assay. f The migration abilities enhanced by downregulated FBP1 were restored after co-transfection with circFNDC3B-218aa using wound-healing assay. g The glucose uptake, h pyruvate production, i lactate production, j ATP status in HCT116 and DLD1 cell lines. **P < 0.01, ***P < 0.001