Table 2.

Summary of interactions between three enteric coronaviruses or PRRSV and the host innate immune response.

	PEDV	SADS-CoV	PDCoV	PRRSV
IFN-β production	○/×	○/×	○/×	○/×
Phosphorylation and nuclear translocation of IRF-3	○/×	○/×	○/×	○/×
Phosphorylation and nuclear translocation of NF-κB	↑/√	○/×	○/×	no information
IRF3-mediated IFN-β production	no information	○	↓	○
TBK1/IKKε-mediated IFN-β production	○	○	↓	○
IPS-1-mediated IFN-β production	↓	↓	↓	↓
RIG-I-mediated IFN-β production	↓	↓	↓	↓
MDA5-mediated IFN-β production	on information	no information	↓	no information
Target molecules	IPS-1	IPS-1 and RIG-I	IRF3	IPS-1
Reference	Cao et al., 2015		Luo et al., 2016	Luo et al., 2008

↓: significant decline.

↑: higher than mock.

○: same as mock.

√: induce.

×: inhibit.