Table 1. Eastern Substituents: In Vitro Antiplasmodium Activity, Solubility, and Cytotoxicity Data of the Compounds with Reduced Basicity.

^aMean from n values of ≥2 independent experiments with sensitive (NF54) and multidrug-resistant (K1) strains of P. falciparum.

^bAqueous solubility using high-performance liquid chromatography (HPLC)-diode array detector (DAD)-mass spectrometry (MS).

^cCHO = Chinese hamster ovarian cell line.

^dSelectivity index (SI) = [IC₅₀ (CHO)/IC₅₀ (PfNF54)].

^eData from Singh et al.³³ ND = not determined.