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. 2020 Mar 17;5(12):6967–6982. doi: 10.1021/acsomega.0c00327

Table 3. In Vitro Antiplasmodium Activity, Solubility, and Cytotoxicity Data of the Western Substituent with Different Substituents in 5-Position.

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a

Mean from n values of ≥2 independent experiments with multidrug-resistant (K1) and sensitive (NF54) strains of P. falciparum.

b

Aqueous solubility using HPLC-DAD-MS.

c

CHO = Chinese hamster ovarian cell line.

d

Selectivity index (SI) = [IC50 (CHO)/IC50 (PfNF54)].

e

Obtained from NOVARTIS screening library and Pf activity determined at NITD. ND = not determined.